In order for Internet Services to be able to respond to perl scripts you must modify the AddHandler document found in the Internet Services folder
Add the following lines to your AddHandler document, changing the drive letter if you have installed ActivePerl on a drive other than C: drive.
<AddHandler pl>
Site: *
exec: c:\perl64\bin\perl.exe
</AddHandler>
Add the following lines to your AddHandler document.
<AddHandler .pl>
Site: *
exec: /usr/bin/perl
</AddHandler>